Tumor Necrosis Factor-alpha Gene Expression in PBMCs of Iranian Azeri Turkish Patients with Premature Coronary Artery Disease (Age ≤50 Years)
نویسندگان
چکیده
منابع مشابه
Evaluation of Tumor necrosis factor-alpha in patients with Coronary Artery Disease
Background: Tumor necrosis factor-α (TNF-α) is a multifunctional circulating cytokine derived from endothelial and smooth muscle cells as well as macrophages associated with coronary atheroma. A large number of genetic and epidemiological studies have identified TNF-α as a risk factor for atherosclerotic disease such as Coronary Artery disease and stroke. Based on our knowledge, this is the fir...
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Behçet's disease (BD) is a complex chronic relapsing inflammatory disorder of unknown etiology. Alterations of the tumor necrosis factor (TNF) expression related to the polymorphic alleles of TNF gene may implicate a pathogenetic role in increased activity of this cytokine in BD. A current study aimed at investigating the possible association between BD and its clinical features in Iranian Azer...
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Background & Aims: Recent studies have shown that some of the MEFV gene mutations are common in patients with coronary artery disease. The present study was designed to investigate the presence or absence of E148Q mutation in exon 2 of MEFV gene in patients with premature coronary artery disease. Materials & Methods: In this study, 90 patients with coronary artery disease were voluntarily sele...
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Objective: The goal of this research was to determine the influence of 4 weeks aerobic training on gene expression of tumor necrosis factor alpha (TNF-α), hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) in the cardiac tissue of diabetic rats. Materials and Methods: In an experimental study, 30 male wistar rats were partitioned into three groups (n=10), d...
متن کاملIL-23 Gene Expression in PBMCs of Patients with Coronary Artery Disease
OBJECTIVE Both adaptive and innate immune systems are involved in coronary artery disease (CAD). The aim of this study was to evaluate TH17 cytokines expression profiles in un-stimulated peripheral blood lymphocytes (PBMCs) of patients with coronary artery disease. METHODS Expression profiles of IL-17, IL-23, and TGF-β1 were determined in individuals with and without CAD using Real-time PCR. ...
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ژورنال
عنوان ژورنال: MAEDICA – a Journal of Clinical Medicine
سال: 2018
ISSN: 1841-9038,2069-6116
DOI: 10.26574/maedica.2018.13.1.12